Prone positioning offers limited benefit in preventing ventilation escalation among infants with bronchiolitis
Placing infants with moderate-to-severe acute viral bronchiolitis in the prone position while receiving high-flow nasal cannula (HFNC) support did not significantly lower the likelihood of escalation to noninvasive or invasive ventilation, according to results of the PROPOSITIS multicentre randomised clinical trial published in JAMA. The findings, drawn from 15 French paediatric intermediate and ICUs, leave open the question of whether prone positioning offers a meaningful benefit in this population, with the authors noting that a wide confidence interval (CI) around the observed effect est...
Maternal RSV vaccination reduces infant hospitalisations by nearly 70%
Maternal vaccination with the bivalent respiratory syncytial virus prefusion F (RSVpreF) vaccine was associated with a 67.6% reduction in RSV-related acute respiratory illness hospitalisations and a 69.0% reduction in RSV-related lower respiratory tr...
Omalizumab shows favourable safety profile in very young children with food allergies
An interim analysis of the OUtMATCH trial found that omalizumab had a safety profile comparable to placebo in children aged 1 to 5 years with multiple food allergies, with most adverse events being mild and no treatment-related anaphylaxis reported. ...
