Recent progress in the diagnosis and treatment of primary aldosteronism
Primary aldosteronism (PA) is caused by excessive secretion of aldosterone from the adrenal glands, with subsequent changes in the renin-angiotensin system. In Japan, chemiluminescent enzyme immunoassay is currently performed for aldosterone assay rather than the earlier method of radioimmunoassay. This change in aldosterone measurement methods has resulted in faster and more accurate measurement of blood aldosterone levels. Since 2019, esaxerenone, a mineralocorticoid receptor antagonist (MRA) with a non-steroidal skeleton, has been available in Japan for the treatment of hypertension. Esaxer
Using COVID-19-Positive Donor Hearts May Impact Post-Transplant Survival
Heart transplant recipients receiving organs from active COVID-19 positive donors may have an increased risk of death at 6 months and 1 year when compared with those receiving organs from patients who recently recovered from COVID-19 or COVID-19-nega...
The Use of Donor Hearts 50 Year-Old or Greater to Septuagenarians in Heart Transplantation
BACKGROUND The impact of using donors ≥50 year-old on the heart transplant outcomes of septuagenarians is unknown, which may have a potential to expand the donor pool. METHODS From Jan 2011 to Dec 2021, 817 septuagenarians received donor hea...
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