HER2 treatment landscape 2023

Professor Javier Cortés, Head of the International Breast Cancer Center in Barcelona, Spain explains the HER2 treatment landscape in 2023. The interview answers the following questions: 1.    HER2-targeting antibody-drug conjugates, T-DM1 and T-DXd have remarkably improved overall survival in patients with HER2-positive mBC. Why do these modern ADCs work so well, what makes them different from previous HER2-targeted therapies? 2.    In the current guidelines, the gold standard first line treatment for HER2-positive mBC is indisputably the dual HER2-blockade plus taxane (CLEOPATRA-regime). Do you think it will change in the (near) future?  3.    As survival is being prolonged, we see more and more patients with brain metastases. How does the presence of brain mets influence your treatment decisions in the second line? 4.    Historically, breast cancers have been defined as HER2-positive or negative. Recently, DesitinyBreast04 established HER2-low as a new targetable population. Will the HER2 expression spectrum broaden even further in the future?  5.    What have we learnt so far from trials of T-DM-1 and T-DXd in earlier disease stages?

What's new in treatment of breast cancer? - Highlights of ESMO BC 2023

Prof. Matteo Lambertini explains the highlights of the 2023 ESMO Breast Cancer Conference.  - There are more insights of the toxicity of the new ACDs, paticullary for trastuzumab deruxtecan. Updated data on the DESTINY (DESTINY-Breast04, 02) trials in the terms of toxicities. - CAPItello-291, capivasertib to fulvestrant improves progression-free survival for key subgroups of patients with hormone receptor-positive, HER2-negative advanced breast cancer resistant to aromatase inhibitors. - The updated result of IMpassion031, the authors presented survival outcomes for this studies. - Highlights the result of the recently published positive study about the safety of temporarly interrupting endocrine therapy to attempt pregnancy after breast cancer.