Hot topics in melanoma management

We asked Professor Paolo Ascierto, world known expert in the field of skin cancer treatment about hot topics in melanoma management. Based on the current evidence, clinical trial data and real world data, what seems to be the best sequence? Open questions include topics in melanoma management the need of adjuvant treatment for high risk pts. What are the pros and cons of adjuvant therapy? Is it still needed or is neoadjuvant therapy the way forward instead of adjuvant therapy?