A once-daily “polypill” combining 3 guideline-recommended heart failure (HF) drugs improved heart function, medication adherence, and clinical outcomes over 6 months, compared with prescribing the same medicines as separate pills, according to a randomised trial led by UT Southwestern Medical Center researchers and published in Nature Medicine. The POLY-HF study enrolled 212 individuals to test whether simplifying complex regimens could help more patients with heart failure with reduced ejection fraction (HFrEF) achieve optimal therapy. "Despite the existence of medical therapies for [HF] t...
Placing infants with moderate-to-severe acute viral bronchiolitis in the prone position while receiving high-flow nasal cannula (HFNC) support did not significantly lower the likelihood of escalation to noninvasive or invasive ventilation, according ...
Maternal vaccination with the bivalent respiratory syncytial virus prefusion F (RSVpreF) vaccine was associated with a 67.6% reduction in RSV-related acute respiratory illness hospitalisations and a 69.0% reduction in RSV-related lower respiratory tr...